Advances in stem cell research and therapeutic development

Nat Cell Biol. 2019 Jul;21(7):801-811. doi: 10.1038/s41556-019-0344-z. Epub 2019 Jun 17

. Advances in stem cell research and therapeutic development.

De Luca M, Aiuti A, Cossu G, Parmar M, Pellegrini G, Robey PG

ABSTRACT
Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials. Finally, we analyse the scientific rationale, experimental approaches, caveats and results underpinning the clinical use of such stem cells.

PMID: 31209293 DOI: 10.1038/s41556-019-0344-z