RESEARCH & DEVELOPMENT

Holostem Terapie Avanzate’s pipeline includes Advanced Therapy Medicinal Products at different stage of development.

ProductIndicationPreclinicalPhase I/II
Phase III
Regulatory Approval
Ex vivo reconstructed autologous human corneal epithelium containing stem cellsLimbal stem cell deficiencyConditional Approval
Ex-vivo-expanded autologous human keratinocytes containing epidermal stem cells transduced with a LAMB3-encoding retroviral vectorJunctional Epidermolysis Bullosa
Ex-vivo-expanded autologous human keratinocytes containing epidermal stem cells transduced with a COL7-encoding retroviral vectorDystrophic Epidermolysis Bullosa
Ex-vivo-expanded autologous human keratinocytes containing epidermal stem cells transduced with a COL17A1-encoding retroviral vectorJunctional Epidermolysis Bullosa

Our research activity is aimed to develop new protocols for cell and gene therapy based on different types of epithelial stem cells.

GMP Facility

Holostem Terapie Avanzate runs a 2.000 sq meters GMP facility (AIFA decree n. aAMM-169/2014) located into the Centre for Regenerative Medicine “Stefano Ferrari” of Modena, one of the biggest research centers in the world entirely dedicated to epithelial stem cells cultures.

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THE CENTRE

The Centre for Regenerative Medicine “Stefano Ferrari” (CMR) of the University of Modena and Reggio Emilia is a 4-floor building of 4.000 sq meters.
CMR fulfills international GMP requirements for cell-based advanced therapies.

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Research & development

Holostem Terapie Avanzate’s pipeline includes Advanced Therapy Medicinal Products at different stage of development. Our research activity is aimed to develop new protocols for cell and gene therapy based on different types of epithelial stem cells.

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