Holostem Terapie Avanzate’s pipeline includes Advanced Therapy Medicinal Products at different stage of development.
Product | Indication | Preclinical | Phase I/II | Phase III | Regulatory Approval | ||
Ex vivo reconstructed autologous human corneal epithelium containing stem cells | Limbal stem cell deficiency | Conditional Approval | |||||
Ex-vivo-expanded autologous human keratinocytes containing epidermal stem cells transduced with a LAMB3-encoding retroviral vector | Junctional Epidermolysis Bullosa | ||||||
Ex-vivo-expanded autologous human keratinocytes containing epidermal stem cells transduced with a COL7-encoding retroviral vector | Dystrophic Epidermolysis Bullosa | ||||||
Ex-vivo-expanded autologous human keratinocytes containing epidermal stem cells transduced with a COL17A1-encoding retroviral vector | Junctional Epidermolysis Bullosa |
Our research activity is aimed to develop new protocols for cell and gene therapy based on different types of epithelial stem cells.