THERAPIES

Stem Cells & Regenerative Medicine

Tissue integrity and regeneration depend on a population of self-renewing somatic stem cells, above all in constantly renewing tissues. Regenerative Medicine refers to innovative therapies aimed at the permanent restoration of diseased tissues and organs.

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Cell Therapy

Autologous cultures of limbal stem cells are routinely used for corneal regeneration and restoration of visual acuity in patients with severe corneal chemical and thermal burns associated to total unilateral or severe bilateral limbal stem cell deficiency.

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Gene Therapy

Holostem Terapie Avanzate is collaborating with the Centre for Regenerative Medicine “Stefano Ferrari” on the implementation of two Phase I/II clinical trials for ex-vivo gene therapy of different forms of Epidermolysis Bullosa.

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Publications

Our scientist are author of over 150 peer-reviewed publications in major international journals.

Last publication:

Toward Combined Cell and Gene Therapy for Genodermatoses

To date, more than 200 monogenic, often devastating, skin diseases have been described. Because of unmet medical needs, development of long-lasting and curative therapies has been consistently attempted, with the aim of correcting the underlying molecular defect. In this review, we will specifically address the few combined cell and gene therapy strategies that made it to the clinics. Based on these studies, what can be envisioned for the future is a patient-oriented strategy, built on the specific features of the individual in need. Most likely, a combination of different strategies, approaches, and advanced therapies will be required to reach the finish line at the end of the long and winding road hampering the achievement of definitive treatments for genodermatoses

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