Stem Cells & Regenerative Medicine

Tissue integrity and regeneration depend on a population of self-renewing somatic stem cells, above all in constantly renewing tissues. Regenerative Medicine refers to innovative therapies aimed at the permanent restoration of diseased tissues and organs.

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Cell Therapy

Autologous cultures of limbal stem cells are routinely used for corneal regeneration and restoration of visual acuity in patients with severe corneal chemical and thermal burns associated to total unilateral or severe bilateral limbal stem cell deficiency.

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Gene Therapy

Holostem Terapie Avanzate is collaborating with the Centre for Regenerative Medicine “Stefano Ferrari” on the implementation of two Phase I/II clinical trials for ex-vivo gene therapy of different forms of Epidermolysis Bullosa.

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Our scientist are author of over 150 peer-reviewed publications in major international journals.

Last publication:

Living with Keratinocytes

Stem Cell Reports. 2018 Nov 13;11(5):1026-1033. doi: 10.1016/j.stemcr.2018.10.005. Living with Keratinocytes. Pellegrini G, De Luca M. Abstract A feature distinguishing human hematopoietic and epithelial stem cells from other equally fascinating stem cells is…