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Holostem has a highly experienced management team, with a sound know-how derived from a long tenure both in business administration and in academic research, successfully applied since many years in translational medicine.

Our Company

Holostem is the first biotechnological company entirely devoted to development, manufacture, registration and distribution of Advanced Therapies Medicinal Products (ATMPs) based on cultures of epithelial stem cells both for cell and gene therapy.

Scientific Background

Our pipeline is based on the pivotal work of Michele De Luca and Graziella Pellegrini in the field of epithelial stem cell-mediated cell and gene therapy. Michele De Luca and Graziella Pellegrini are internationally recognized as leading scientists in the field of epithelial stem cell biology aimed at clinical application and played a pivotal role in epithelial stem cell-mediated cell therapy and gene therapy.


Our scientist are author of over 150 peer-reviewed publications in major international journals.

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