A clear cornea is essential to visual acuity and depends on stromal avascularity and epithelial integrity. Corneal renewal and repair are mediated by stem cells of the limbus, the narrow zone between the cornea and the bulbar conjunctiva.
Ocular burns may destroy the limbus, causing limbal stem cell deficiency. In such cases, the cornea acquires an epithelium through the invasion of bulbar conjunctival cells.
This process leads to neovascularization, chronic inflammation and stromal scarring,
with corneal opacity and loss of vision.
In this clinical setting, allogeneic corneal transplantation (keratoplasty) is unsuccessful.
Eye damaged by corneal burn
Holoclar® is a product of tissue engineering for advanced therapies consisting of an ex vivo reconstructed autologous human corneal epithelium containing stem cells, indicated for the reconstruction of the corneal surface in patients with limbal stem cell deficiency
due to ocular burns. The active substance of Holoclar® is represented by the epithelial
stem cells contained therein, that engraft and permanently regenerate a functional
corneal epithelium allowing recovery of visual acuity.
Holoclar®'s Marketing Authorization holder is Chiesi Farmaceutici S.p.A.
Cultured sheet of corneal epithelium (Holoclar®)
STEM CELL-BASED THERAPY
FOR CORNEAL SURFACE REGENERATION
Holostem Terapie Avanzate is collaborating with the Centre for Regnerative Medicine "Stefano Ferrari" on the implementation
of two Phase I/II clinical trials
for ex-vivo gene therapy
of different forms of
Provide patients suffering from
severe or rare, untreatable diseases
with stem cell-based advanced therapies
through ethical and scientific excellence
© 2017 Holostem Terapie Avanzate S.r.l.
VAT: 03213240363 -
Payed Up Capital: Euro 700.000,00
Companies Register Office - Modena: 03213240363
Registered with the Administrative Economic Register: MO-368370
Company subject to the management and coordination of Valline s.r.l.
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Tissue integrity and regeneration depend on a population of self-renewing somatic stem cells, above all in constantly renewing tissues. Regenerative Medicine refers to innovative therapies aimed at the permanent restoration of diseased tissues and organs...