REGENERATIVE MEDICINE

FROM BENCH TO BEDSIDE




A clear cornea is essential to visual acuity and depends on stromal avascularity and epithelial integrity. Corneal renewal and repair are mediated by stem cells of the limbus, the narrow zone between the cornea and the bulbar conjunctiva.


Ocular burns may destroy the limbus, causing limbal stem cell deficiency. In such cases, the cornea acquires an epithelium through the invasion of bulbar conjunctival cells.

This process leads to neovascularization, chronic inflammation and stromal scarring,

with corneal opacity and loss of vision.

In this clinical setting, allogeneic corneal transplantation (keratoplasty) is unsuccessful.













Eye damaged by corneal burn


Holoclar® is a product of tissue engineering for advanced therapies consisting of an ex vivo reconstructed autologous human corneal epithelium  containing stem cells, indicated for the reconstruction of the corneal surface in patients with limbal stem cell deficiency

due to ocular burns. The active substance of Holoclar® is represented by the epithelial

stem cells contained therein, that engraft and permanently regenerate a functional

corneal epithelium allowing recovery of visual acuity.


Holoclar®'s Marketing Authorization holder is Chiesi Farmaceutici S.p.A.














Cultured sheet of corneal epithelium (Holoclar®)


STEM CELL-BASED THERAPY

FOR CORNEAL SURFACE REGENERATION

GENE THERAPY

Holostem Terapie Avanzate is collaborating with the Centre for Regnerative  Medicine "Stefano Ferrari" on the implementation

of two Phase I/II clinical trials

for ex-vivo gene therapy

of different forms of

Epidermolysis Bullosa...

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STEM CELLS

TECHNOLOGY

GENE THERAPY

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MISSION


Provide patients suffering from

severe or rare, untreatable diseases

with stem cell-based advanced therapies

through ethical and scientific excellence

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PUBLICATIONS

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© 2017  Holostem Terapie Avanzate S.r.l.


VAT: 03213240363 -

Payed Up Capital: Euro 700.000,00

Companies Register Office - Modena: 03213240363

Registered with the Administrative Economic Register: MO-368370

Company subject to the management and coordination of Valline s.r.l.

FOLLOW US ON

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PUBLICATIONS

Our scientist are author of over 150 peer-reviewed publications in major international journals...


ABOUT US

STEM CELLS & REGENERATIVE MEDICINE

Tissue integrity and regeneration depend on a population of self-renewing somatic stem cells, above all in constantly renewing tissues. Regenerative Medicine refers to innovative therapies aimed at the permanent restoration of diseased tissues and organs...


Holostem Terapie Avanzate Srl

joins Clust-ER Association

"Life Sciences and Wellbeing"


June 2, 2017

NEWS